7 RESULTS
COMMENT This work on a γ-secretase-modulating protein IFITM3 published by Yue-Ming Li's group is a sequel to his Nature article on presenilin-labeling active site γ-secretase inhibitors published in 2000. The γ-secretase complex and its modulators have been
COMMENT Jung et al. have discovered SERP1, a facilitator for the assembly of the γ-secretase complex and the generation of amyloid β protein (Aβ). They did an excellent job in dissecting the molecular architecture of SRRP1-APH1A/Nicastrin, and provided detailed i
COMMENT Cakir et al. have established a brain organoid model carrying a vascular-like system that functions in implanted mice. This system is unique in many ways compared with previous published brain organoids, and it has tremendous potential for testing therape
COMMENT An ELISA-based biochemical measurement of oligomeric Aβ (oAβ) species from human fluids such as CSF has been enthusiastically anticipated in the field, in light of extensive in vitro and in vivo studies of neurotoxic oAβ and its direct and indirect effect
COMMENT To keep apoptosis in check, it may be best to avoid the ups and downs of γ-secretase. Zebrafish lacking the γ-secretase component Pen-2 induce p53-dependent apoptosis throughout the body (Campbell et al., 2006), while mice lacking the Aph-1A component dem
COMMENT Do presenilin enhancer 2 (PEN-2) and presenilin 2 (PS2) cytosolic loops have something in common? In this paper, Cai et al. report the initiation and acceleration of cellular apoptosis by a 22-mer peptide that is usually generated by presenilinase and cas
COMMENT The findings by Li et al. on the regulation of APP processing by sumoylation indeed bring a new perspective to the field of AD research. Although the authors documented a lack of direct sumoylation of APP and BACE, they have demonstrated a clear increase
